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This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks!'
Macrophage Elastase
Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a active-site cleft.
Reference:
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| 1jk3, resolution 1.09Å () | |||||||||
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| Ligands: | , , | ||||||||
| Activity: | Macrophage elastase, with EC number 3.4.24.65 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
