2jm6
From Proteopedia
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Solution structure of MCL-1 complexed with NOXAB
Overview
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family., The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa, to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding, of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We, compared the three-dimensional structures of the complexes formed between, BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal, sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.
About this Structure
2JM6 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural insights into the degradation of Mcl-1 induced by BH3 domains., Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:17389404
Page seeded by OCA on Wed Jan 23 15:18:56 2008
Categories: Mus musculus | Protein complex | Colman, P.M. | Czabotar, P.E. | Day, C.L. | Delft, M.F.van. | Fairlie, W.D. | Hinds, M.G. | Huang, D.C.S. | Lee, E.F. | Smith, B.J. | Apoptosis | Bcl-2 | Bh3-only | Helical bundle | Mcl-1
