2of6
From Proteopedia
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Structure of immature West Nile virus
Overview
The structures of immature West Nile virus particles, propagated in the, presence of ammonium chloride to block virus maturation in the low pH, environment of the trans-Golgi network, were determined by cryoelectron, microscopy. The structures of these particles were similar to immature, West Nile virus particles found as a minor component of mature virus, samples ("naturally-occurring immature particles", NOIPs). The structure, of mature infectious flavivirus is radically different to that of the, immature particles. The similarity of the ammonium chloride-treated, particles and NOIPs suggests that either the NOIPs have not undergone any, conformational change during maturation or that the conformational change, is reversible. Comparison with immature dengue virus reconstructions, established the location of the N-linked glycosylation sites of these, viruses, verifying the interpretation of the reconstructions of the, immature flaviviruses.
About this Structure
2OF6 is a Single protein structure of sequence from West nile virus. Full crystallographic information is available from OCA.
Reference
Structure of Immature West Nile Virus., Zhang Y, Kaufmann B, Chipman PR, Kuhn RJ, Rossmann MG, J Virol. 2007 Mar 21;. PMID:17376919
Page seeded by OCA on Wed Jan 23 15:04:05 2008
