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NS5B

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Revision as of 06:09, 20 April 2009 by Nicolas Villanueva (Talk | contribs)
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NS5B, the RNA Dependent RNA Polymerase from Hepatitis C Virus

PDB ID 2HAI

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Image:1NB4 4domains.jpg

PDB IDs 2HAI (protein) 1RTD (DNA)

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NS5B with B form DNA from HIV Reverse Transcriptase co-crystal model. DNA was modeled in by alignment of palms domain. A beta hairpin in the thumb domain has been moved to accommodate DNA, the hairpin is modeled into the minor groove, a possible binding site. Catalytic Mg2+ ions are modeled in green, these would be coordinated by the three aspartic acid carboxylates, (D220, D318 and D319).

The template strand is seen entering through a gap in the fingers domain, incoming nucleotide that extends the primer lines up with the NS5B active site and duplex DNA exits the enzyme through the large central hole.

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