Rebecca Martin/Sandbox1

From Proteopedia

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Contents 1 Introduction 2 General Structure 3 IgA1 and IgA2 4 Secretory Component and Polyimmunoglobulin receptor 5 Insights into Function 6 Evolution 7 Implications in Science and Medicine 8 Limitations of the Current Studies 9 Questions for the Future 10 Links 10.1 IgA 10.2 Receptors 10.3 Other Isotypes (for comparison) 11 References

Introduction

IgA1

Template:STRUCTURE 3cm9

General Structure

• Antibody Structure
• Dimeric Structure

• Secretory Component

IgA1 and IgA2

spinqualitylabelsall models IgA2 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

spinqualitylabelsall models IgA1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Secretory Component and Polyimmunoglobulin receptor

spinqualitylabelsall models This is the secretory component. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Insights into Function

Evolution

Implications in Science and Medicine

Limitations of the Current Studies

Because of the nature of the IgA molecule, crystalizing this structure was not possible. Therefore, many of these structures are based on models and not actual crystal structures. Because ...., the models were depositable in the PDB. I tried to include other crystallographic data when available, supporting the proposed models- as the authors did in the original papers.

Questions for the Future

Because of the limitating resolution of these models, many details concerning the binding residues and residue interactions are left unknown. Crystallographic structure will yield further insights into the structure of IgA, the interactions between IgA and other molecules, and ....

Links

IgA

• Monomeric

Model of human IgA1 determined by solution scattering, curve-fitting, and homology modeling 1iga

Model of human IgA2 determined by solution scattering, curve fitting and homology modelling 1r70

• Fab and Fc Fragments

Refined crystal structure of the galactan-binding immunoglobulin fab j539 at 1.95-angstroms resolution 2fbj

Phosphocholine binding immunoglobulin fab mc/pc603. an x-ray diffraction study at 2.7 angstroms 1mcp

Crystal structure of human FcaRI bound to IgA1-Fc 1ow0

• Dimeric and Secretory

Solution structure of human dimeric immunoglobulin A 2qtj

Solution structure of human secretory IgA1 3chn

Solution Structure of Human SIgA2 3cm9

Solution structure of human secretory component 2ocw

Receptors

• Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR 1XED
• Crystal structure of human FcaRI 10vz
• Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 2qej

Other Isotypes (for comparison)

• IgM: Solution structure of human Immunoglobulin M 2rcj
• IgG:
• IgD:
• IgE:

References