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Introduction to IgA
Template:STRUCTURE 1iga The most extensive surface in contact with the external environment is not our skin, but the epithelial lining of our gastrointestinal, respiratory, and urogenital tracts [1]. As a first line of defense in maintainance the integrity our mucosa, the immune system manufatures and secretes dimeric IgA to neutralize pathogenic organisms [2] and exclude the entry of commensals at the mucosal border [3]. In the serum, IgA functions as a second line of defense against pathogens that may breech the epithelial boundary [2].
Unlike other antibody isotypes, IgA exists in mutiple oligomeric states [3]
