3h1v

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Template:STRUCTURE 3h1v

Contents 1 Human glucokinase in complex with a synthetic activator 2 Disease 3 About this Structure 4 Reference

Human glucokinase in complex with a synthetic activator

Template:ABSTRACT PUBMED 19736020

Disease

Known disease associated with this structure: Diabetes mellitus, gestational OMIM:[138079], Diabetes mellitus, noninsulin-dependent, late onset OMIM:[138079], Diabetes mellitus, permanent neonatal OMIM:[138079], Hyperinsulinemic hypoglycemia, familial, 3 OMIM:[138079], MODY, type II OMIM:[138079]

About this Structure

3H1V is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Takahashi K, Hashimoto N, Nakama C, Kamata K, Sasaki K, Yoshimoto R, Ohyama S, Hosaka H, Maruki H, Nagata Y, Eiki J, Nishimura T. The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg Med Chem. 2009 Oct 1;17(19):7042-51. Epub 2009 May 21. PMID:19736020 doi:10.1016/j.bmc.2009.05.037

Page seeded by OCA on Wed Oct 7 14:04:44 2009