3h6v

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Image:3h6v.png

Template:STRUCTURE 3h6v

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5206 at 2.10 A resolution

Template:ABSTRACT PUBMED 19591837

About this Structure

3H6V is a 2 chains structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Hald H, Ahring PK, Timmermann DB, Liljefors T, Gajhede M, Kastrup JS. Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J Mol Biol. 2009 Sep 4;391(5):906-17. Epub 2009 Jul 8. PMID:19591837 doi:10.1016/j.jmb.2009.07.002
  • Armstrong N, Gouaux E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron. 2000 Oct;28(1):165-81. PMID:11086992
  • Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E. Mechanism of glutamate receptor desensitization. Nature. 2002 May 16;417(6886):245-53. PMID:12015593 doi:10.1038/417245a

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