3h98

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Image:3h98.jpg

Template:STRUCTURE 3h98

Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative

Template:ABSTRACT PUBMED 19500983

About this Structure

3H98 is a 2 chains structure of sequences from Viruses. Full crystallographic information is available from OCA.

Reference

  • Wang G, Lei H, Wang X, Das D, Hong J, Mackinnon CH, Coulter TS, Montalbetti CA, Mears R, Gai X, Bailey SE, Ruhrmund D, Hooi L, Misialek S, Rajagopalan PT, Cheng RK, Barker JJ, Felicetti B, Schonfeld DL, Stoycheva A, Buckman BO, Kossen K, Seiwert SD, Beigelman L. HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4480-3. Epub 2009 May 9. PMID:19500983 doi:10.1016/j.bmcl.2009.05.022

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