3hkj

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Template:STRUCTURE 3hkj

Contents 1 Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1 2 Disease 3 About this Structure 4 Reference

Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

3HKJ is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:http://dx.doi.org/10.1074/jbc.M407272200

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