User:Tilman Schirmer/Sandbox 201

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Contents

Diguanylate cyclases

PleD

Intro


Domain structure


Protomer


Substrate binding site


Allosteric product binding site


C-di-GMP


Primary inhibition site (Ip)


Secoondary inhibition site (Is)


Two conformations

non-activated (1w25)
non-activated (1w25)
activated (BeF3- modified; 2v0n
activated (BeF3- modified; 2v0n



Non-activated conformation

1w25

1w25

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Activated conformation

2v0n

2v0n

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WspR

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Tilman Schirmer

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