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3i5n

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Revision as of 11:54, 13 January 2010 by OCA (Talk | contribs)
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Image:3i5n.jpg

Template:STRUCTURE 3i5n

Contents

Crystal structure of c-Met with triazolopyridazine inhibitor 13

Template:ABSTRACT PUBMED 19819693

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

3I5N is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Boezio AA, Berry L, Albrecht BK, Bauer D, Bellon SF, Bode C, Chen A, Choquette D, Dussault I, Fang M, Hirai S, Kaplan-Lefko P, Larrow JF, Lin MH, Lohman J, Potashman MH, Qu Y, Rex K, Santostefano M, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Harmange JC. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6307-12. Epub 2009 Sep 27. PMID:19819693 doi:10.1016/j.bmcl.2009.09.096

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