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3ghv

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Revision as of 05:46, 23 September 2009 by OCA (Talk | contribs)
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Image:3ghv.jpg

Template:STRUCTURE 3ghv

Human dihydrofolate reductase Q35K/N64F double mutant inhibitor complex

Template:ABSTRACT PUBMED 19719239

About this Structure

3GHV is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gangjee A, Li W, Kisliuk RL, Cody V, Pace J, Piraino J, Makin J. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. J Med Chem. 2009 Aug 13;52(15):4892-902. PMID:19719239 doi:10.1021/jm900490a

Page seeded by OCA on Wed Sep 23 08:46:48 2009

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