Proteins involved in cancer
From Proteopedia
Proteins involved in Cancer
Wabash College's Che 461 course, "The Chemistry of Cancer," explored the major pathways and proteins involved in the development of cancer. This page is a compliation of their work.
Cancer is a complex disease, that arises after an accumulation of alterations of normal cellular pathways. Cells can have altered responses to growth signals, deviations in cell cycle controls, or lose the capacity to undergo apoptosis when processes are not happening normally. Generally, there must be at least two defects for cancer to happen--one to inappropriately trigger cell division, and a second, loss of regulation. This is called the "two hit hypothesis".
Signal transduction
Signal transduction is the process where cells detect their environment and respond to these cues. Most growth cues funnel through receptor tyrosine kinase pathways.
