Inositol 1,4,5-Trisphosphate Receptor

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Shannon King

Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.

spinqualitylabelsall models Inositol 1,4,5-triphosphate receptor Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Inositol 1,4,5-trisphosphate receptor binding protein is a ubiquitous protein involved in the Ca²⁺ signalling processes in a variety of organisms ^[1]

Structure

The specific type of inositol 1,4,5-trisphosphate receptor (InsP₃R)protein discussed here is the mouse type one InsP₃R, also called InsP₃R1. This polypeptide contains three major regions: the amino terminal inositol 1,4,5-trisphosphate (InsP₃) binding region, the central modulatory region, and the carboxy-terminus channel region.¹ The protein forms an L-shaped structure composed of two asymmetric domains perpendicular to each other.^[1] The N-terminal domain is made up of 12 β-strands and 2 single-turn helices.^[1] These components form a barrel. The C-terminal end is quite different, consisting of a bundle made of eight α-helices.^[1] The interface of the two domains is lined with basic residues and forms the receptor site for InsP₃.^[1]

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