3ksy

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Image:3ksy.jpg

Template:STRUCTURE 3ksy

Contents

Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras activator Son of Sevenless (SOS)

Template:ABSTRACT PUBMED 20133692

Disease

Known disease associated with this structure: Fibromatosis, gingival OMIM:[182530], Noonan syndrome 4 OMIM:[182530], Noonan-like/multiple giant cell lesion syndrome OMIM:[182530]

About this Structure

3KSY is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gureasko J, Kuchment O, Makino DL, Sondermann H, Bar-Sagi D, Kuriyan J. Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc Natl Acad Sci U S A. 2010 Feb 4. PMID:20133692

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