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Prolyl Endopeptidase

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Revision as of 19:39, 24 March 2010 by Stacey Shantz (Talk | contribs)
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Prolyl endopeptidase of Sphingomonas capsulata

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Prolyl endopeptidases (PEPs) are a class of serine proteases known to have a role in the degradation of neuropeptides and peptide hormones. PEPs are large enzymes (75kDa) that cleave after proline residues in the peptide chain.

Contents

Structure

β-Propeller Domain

Catalytic Domain

Function

Binding Mechanism

Inhibition

Pharmaceutical Possibilities

Celiac Disease

Neurological Disorders

References

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