Glycerol-3-Phosphate Dehydrogenase

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Glycerol 3-Phosphate Dehydrogenase

Template:STRUCTURE 2r4e

Contents 1 Introduction 1.1 Structure 1.2 Function 1.2.1 Metabolism 1.3 Diseases

Introduction

Glycerol 3-Phosphate Dehydrogenase (GlpD) is an oxidoreductase enzyme which catalyze the reaction of transfer of electrons between molecules. GlpD is a membrane associated enzyme that is involved in glycerol metabolism, ubiquinone and glyceroneogenesis in E. coli. In Ecoli, many newly discovered structures of GlpD are being used to transfer electrons into the respiratory pathway and also for the metabolism of glycerol into its precursors for other pathways. The GlpD enzyme contains a flavin active site which plays a major role in the respiratory electron transport chain and in cellular energy requirements.

Structure

GlpD consists of two chains; α and β.

Function

GlpD is associated in the intracellular membrane of E. coli and in the inner-mitochondrial membrane of eukaryotes. GlpD in E. Coli catalyzes the reaction and oxidizes glycerol 3-phosphate to dihydroxyacetone phosphate in the glycerol metabolic pathway. Upon the oxidation of glycerol 3-phosphate, falvin adenine dinucleotide (FAD) reduces to FADH2, passing on electrons to Ubiquinone (UQ). UQ then reduces to UQH2 which allows for electrons to pass to nitrate or oxygen.

Metabolism

Diseases

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