Sandbox max quiz 2

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1.

Position of protein in relation to membrane bilayer (red represents periplasmic side while blue represents cytoplasmic layer) (2oau).

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Morph: 2oau to 2vv5.

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{Using the scene to the right showing the structure of E. coli McsS as well as the morph between the open and closed conformation, which side undergoes the most major conformational change.

Cytosolic
Periplasmic
→ Why might the smaller periplasmic side be the site of conformational shifting? What other functions might the cytoplasmic domain serve?

2. The following link connects to a page detailing Glucokinase which is a specific form of hexokinase and plays a special role in glycolysis. Unlike other hexokinases glucokinase has low affinity and is not product inhibited. What specific functions might glucokinase serve in the cell?

rapid consumption of glucose
continued glucose phosphorylation in high glucose concentrations regardless of downstream product concentrations
signaling for glycogen activation
phosporylating the majority of glucose in glycolysis

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