Molecular playground/beta 2 microglobulin
From Proteopedia
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is a 12kd protein that self-assembles into amyloid fibrils in the presence of copper. This reaction is considered a likely cause for dialysis related amyloidosis; a disease where these fibrils build up in joints causing pain and eventually necessitating joint replacement.
Fibril assembly begins with the formation of a . This dimer formation is initiated when copper binds near the , this binding causes structural shifts throughout the protein, creating two new . These planes interact in an antiparallel fashion to form the dimer.
