This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2bz5
From Proteopedia
|
STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF HSP90 INHIBITORS
Overview
Docking-based virtual screening identified 1-(2-phenol)-2-naphthol, compounds as a new class of Hsp90 inhibitors of low to sub-micromolar, potency. Here we report the binding affinities and cellular activities of, several members of this class. A high resolution crystal structure of the, most potent compound reveals its binding mode in the ATP binding site of, Hsp90, providing a rationale for the observed activity of the series and, suggesting strategies for developing compounds with improved properties.
About this Structure
2BZ5 is a Single protein structure of sequence from Homo sapiens with AB4 as ligand. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Structure-based discovery of a new class of Hsp90 inhibitors., Barril X, Brough P, Drysdale M, Hubbard RE, Massey A, Surgenor A, Wright L, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5187-91. Epub 2005 Oct 3. PMID:16202589
Page seeded by OCA on Mon Nov 12 21:08:17 2007
