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Severin

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Revision as of 05:52, 2 August 2010 by Alexander Berchansky (Talk | contribs)
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Image:3fg6.png

Template:STRUCTURE 3fg6

Severin is a calcium-activated protein which binds actin. The images at the top and at the right correspond to one representative Severin structure, i.e. human Severin (3fg6). It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from Gelsolin (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is an (each monomer is colored in different color) of the Severin with (colored lime).

3D Structures of Severin

3fg6 – Adseverin C-terminal – human
1svy – Severin domain 2 – Dictyostelium discoideum
1svq - Severin domain 2 - Dictyostelium discoideum, NMR

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky

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