Severin
From Proteopedia
Severin is a calcium-activated protein which binds actin. The images at the top and at the right correspond to one representative Severin structure, i.e. human Severin (3fg6). It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Whole Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from Gelsolin (G1-G6). However, currently are crystallized only three C-terminal domains (A4-A6). It is named Adseverin and Scinderin as well. The image at the right is the Severin with (colored lime).
3D Structures of Severin
3fg6 – Adseverin C-terminal – human
1svy – Severin domain 2 – Dictyostelium discoideum
1svq - Severin domain 2 - Dictyostelium discoideum, NMR
