Cyclophilin

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Image:2x25.png
Crystal Structure of human Cyclophilin-A, 2x25

Template:STRUCTURE 2x25

Cyclophilin (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug.

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Michal Harel, Alexander Berchansky

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