1gzc
From Proteopedia
|
HIGH-RESOLUTION CRYSTAL STRUCTURE OF ERYTHRINA CRISTAGALLI LECTIN IN COMPLEX WITH LACTOSE
Overview
The primary sequence of Erythrina cristagalli lectin (ECL) was mapped by, mass spectrometry, and the crystal structures of the lectin in complex, with lactose and 2'-alpha-L-fucosyllactose were determined at 1.6A and, 1.7A resolution, respectively. The two complexes were compared with the, crystal structure of the closely related Erythrina corallodendron lectin, (ECorL) in complex with lactose, with the crystal structure of the Ulex, europaeus lectin II in complex with 2'-alpha-L-fucosyllactose, and with, two modeled complexes of ECorL with, 2'-alpha-L-fucosyl-N-acetyllactosamine. The molecular models are very, similar to the crystal structure of ECL in complex with, 2'-alpha-L-fucosyllactose with respect to the overall mode of binding, with the L-fucose fitting snugly into the cavity ... [(full description)]
About this Structure
1GZC is a [Single protein] structure of sequence from [[1]] with LAT, MN and CA as [ligands]. Full crystallographic information is available from [OCA].
Reference
High-resolution crystal structures of Erythrina cristagalli lectin in complex with lactose and 2'-alpha-L-fucosyllactose and correlation with thermodynamic binding data., Svensson C, Teneberg S, Nilsson CL, Kjellberg A, Schwarz FP, Sharon N, Krengel U, J Mol Biol. 2002 Aug 2;321(1):69-83. PMID:12139934
Page seeded by OCA on Mon Oct 29 17:00:51 2007
