Sandbox c12

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TcAChE

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1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.

Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor.

It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease.

is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 ()[1]

  1. ↑ Keighley MR, Asquith P, Edwards JA, Alexander-Williams J. The importance of an innervated and intact antrum and pylorus in preventing postoperative duodenogastric reflux and gastritis. Br J Surg. 1975 Oct;62(10):845-9. PMID:123
pmid 8415649.
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