HIV Protease Resistance
From Proteopedia
| Resistance Mutations | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Visualize | Inhibitor/Mutation Site | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Ritonavir | I,R,V | - | - | M,R | - | - | I | F | - | - | I | - | <red>I,L<red> | - | - | - | - | V,L | - | - | - | - | - | V,T | - | - | - | I | A,F,T,S | - | V | - | - | - | M | - |
| Indinavir | I,R,V | - | - | M,R | I | - | I | - | - | - | I | I,L | - | - | - | - | V | - | - | - | - | - | V,T | S,A | - | - | I | A,F,T | V | - | - | - | M | - | |||
| Visualize | Saquinavir | I,R,V | - | - | - | - | - | - | - | - | - | - | - | - | - | V | - | - | V,L | - | - | - | - | - | V,T | S | - | - | I | A | - | V | - | - | - | M | - |
| Visualize | Nelfinavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Amprenavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Atazanavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Lopinavir & Ritonavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Atazanavir & Ritonavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Darunavir & Ritonavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Fosamprenavir & Ritonavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Indinavir & Ritonavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Saquinavir & Ritonavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
| Visualize | Tipranavir & Ritonavir | L10 | I13 | G16 | K20 | L24 | D30 | V32 | L33 | E34 | E35 | M36 | K43 | M46 | I47 | G48 | I50 | F53 | I54 | D60 | I62 | L63 | I64 | H69 | A71 | G73 | T74 | L76 | V77 | V82 | N83 | I84 | I85 | N88 | L89 | L90 | I93 |
