Cyclooxygenase

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Unhibited mouse cyclooxygenase

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NSAIDs

Drug Coefficient of selectivity (IC50Cox-1/IC50Cox-2)
Ketorolac
100-1000
Naproxen
1-10
Ibuprofen
1-10
Indometacin
1-10
Acetylsalicylic acid
1
Diclofenac
1-0.1
Valdecoxib
0.01-0.001
Etoricoxib
0.01-0.001
Table X: Selectivity of some NSAIDs
Pharmacologic group Drug
Salicylates Acetylsalicylic acid
Propionic Naproxen
Ibuprofen
Para-aminophenols Paracetamol
Indolacetic Indometacin
Pirrolacetic Ketorolac
Phenilacetic Diclofenac
Piranoidacetic Etodolac
Anthranilic Mefenamic acid
Nicotinic Clonixin
Sulfonanilides Nimesulide
Table X: Chemical variety of NSAIDs

Reference

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