1qiw

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Image:1qiw.png

Template:STRUCTURE 1qiw

CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD)

Template:ABSTRACT PUBMED 10731425

About this Structure

1QIW is a 2 chains structure with sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Harmat V, Bocskei Z, Naray-Szabo G, Bata I, Csutor AS, Hermecz I, Aranyi P, Szabo B, Liliom K, Vertessy BG, Ovadi J. A new potent calmodulin antagonist with arylalkylamine structure: crystallographic, spectroscopic and functional studies. J Mol Biol. 2000 Mar 31;297(3):747-55. PMID:10731425 doi:10.1006/jmbi.2000.3607
  • Vandonselaar M, Hickie RA, Quail JW, Delbaere LT. Trifluoperazine-induced conformational change in Ca(2+)-calmodulin. Nat Struct Biol. 1994 Nov;1(11):795-801. PMID:7634090
  • Cook WJ, Walter LJ, Walter MR. Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex. Biochemistry. 1994 Dec 27;33(51):15259-65. PMID:7803388

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