3c09

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Template:STRUCTURE 3c09

Contents 1 Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR 2 Disease 3 About this Structure 4 Reference

Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR

Template:ABSTRACT PUBMED 18394559

Disease

Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]

About this Structure

3C09 is a 6 chains structure of sequences from Homo sapiens and Homo sapiens, mus musculus. Full crystallographic information is available from OCA.

Reference

• Schmiedel J, Blaukat A, Li S, Knochel T, Ferguson KM. Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell. 2008 Apr;13(4):365-73. PMID:18394559 doi:10.1016/j.ccr.2008.02.019

Page seeded by OCA on Sun Mar 22 11:20:43 2009