2vw5

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Image:2vw5.png

Template:STRUCTURE 2vw5

STRUCTURE OF THE HSP90 INHIBITOR 7-O-CARBAMOYLPREMACBECIN BOUND TO THE N- TERMINUS OF YEAST HSP90

Template:ABSTRACT PUBMED 18800759

About this Structure

2VW5 is a 4 chains structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Zhang MQ, Gaisser S, Nur-E-Alam M, Sheehan LS, Vousden WA, Gaitatzis N, Peck G, Coates NJ, Moss SJ, Radzom M, Foster TA, Sheridan RM, Gregory MA, Roe SM, Prodromou C, Pearl L, Boyd SM, Wilkinson B, Martin CJ. Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. J Med Chem. 2008 Sep 25;51(18):5494-7. PMID:18800759 doi:10.1021/jm8006068

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