2r4f

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Template:STRUCTURE 2r4f

Contents 1 Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors 2 Disease 3 About this Structure 4 Reference

Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors

Template:ABSTRACT PUBMED 18072721

Disease

Known disease associated with this structure: Statins, attenuated cholesterol lowering by OMIM:[142910]

About this Structure

2R4F is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H -pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. J Med Chem. 2008 Jan 10;51(1):31-45. Epub 2007 Dec 12. PMID:18072721 doi:10.1021/jm070849r

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