2r2m

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Image:2r2m.png

Template:STRUCTURE 2r2m

Contents

2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors

Template:ABSTRACT PUBMED 17889527

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

2R2M is a 3 chains structure of sequences from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lee L, Kreutter KD, Pan W, Crysler C, Spurlino J, Player MR, Tomczuk B, Lu T. 2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6266-9. Epub 2007 Sep 8. PMID:17889527 doi:10.1016/j.bmcl.2007.09.013

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