2hyy

From Proteopedia

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spinqualitylabelsall models PDB ID 2hyy Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2hyy, resolution 2.40Å ()
Ligands:
Gene:	ABL1 (Homo sapiens)
Activity:	Non-specific protein-tyrosine kinase, with EC number 2.7.10.2
Related:	1iep, 1fpu
Structural annotation: Resources: InterPro : Ipr015015, Ipr000980, Ipr000719, Ipr011009, Ipr001245, Ipr008266, Ipr001452 Pfam : PF07714 UniProt : P00519
Functional annotation: Cellular component: cytoplasm nucleus cytoskeleton Biological process: actin cytoskeleton organization and biogenesis protein amino acid phosphorylation peptidyl-tyrosine phosphorylation intracellular signaling cascade mismatch repair DNA damage response, signal transduction resulting in induction of apoptosis S-phase-specific transcription in mitotic cell cycle regulation of transcription, DNA-dependent cell adhesion protein modification process Molecular function: ATP binding transferase activity protein-tyrosine kinase activity protein C-terminus binding nucleotide binding manganese ion binding magnesium ion binding protein kinase activity kinase activity protein binding DNA binding metal ion binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Human Abl kinase domain in complex with imatinib (STI571, Glivec) 2 Disease 3 About this Structure 4 Reference

Human Abl kinase domain in complex with imatinib (STI571, Glivec)

Template:ABSTRACT PUBMED 17164530

Disease

Known disease associated with this structure: Leukemia, Philadelphia chromosome-positive, resistant to imatinib OMIM:[189980]

About this Structure

2HYY is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Cowan-Jacob SW, Fendrich G, Floersheimer A, Furet P, Liebetanz J, Rummel G, Rheinberger P, Centeleghe M, Fabbro D, Manley PW. Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):80-93. Epub 2006, Dec 13. PMID:17164530 doi:http://dx.doi.org/10.1107/S0907444906047287

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