2ot8

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spinqualitylabelsall models 2ot8, resolution 3.1Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Karyopherin Beta2/Transportin-hnRNPM NLS Complex

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Kapbeta2 (also called transportin) recognizes PY nuclear localization, signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we, show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as, classified by the composition of an additional N-terminal motif, converge, in structure only at consensus motifs, which explains ligand diversity. On, the basis of these data and complementary biochemical analyses, we, designed a Kapbeta2-specific nuclear import inhibitor, M9M.

Disease

Known disease associated with this structure: Deafness, mitochondrial, modifier of OMIM:[610230]

About this Structure

2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768

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