3lox
From Proteopedia
HCV NS3-4a protease domain with a ketoamide inhibitor derivative of Boceprevir bound
Template:ABSTRACT PUBMED 20303756
About this Structure
3lox is a 4 chain structure with sequence from Hepatitis c virus subtype 1a. Full crystallographic information is available from OCA.
Reference
- Bennett F, Huang Y, Hendrata S, Lovey R, Bogen SL, Pan W, Guo Z, Prongay A, Chen KX, Arasappan A, Venkatraman S, Velazquez F, Nair L, Sannigrahi M, Tong X, Pichardo J, Cheng KC, Girijavallabhan VM, Saksena AK, Njoroge FG. The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2617-21. Epub 2010 Feb 19. PMID:20303756 doi:10.1016/j.bmcl.2010.02.063
