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Contents 1 Porphobilinogen Deaminase 2 Function 3 Structure 4 References

Porphobilinogen Deaminase

spinqualitylabelsall models PDB ID 3eq1 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
3eq1, resolution 2.80Å ()
Ligands:	,
Activity:	Hydroxymethylbilane synthase, with EC number 2.5.1.61
Structural annotation: Resources: InterPro : Ipr000860 Pfam : PF01379, PF03900 UniProt : P08397
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Porphobilinogen deaminase (PBGD) also known as Hydroxymethylbilane synthase, is the third enzyme in the heme biosynthesis pathways in mammals^[1]. It catalyses the polymerization of four porphobilinogen molecules to yield hydroxymethylbilane^[2]

Function

Structure

References

1. ↑ Gill R, Kolstoe SE, Mohammed F, Al D-Bass A, Mosely JE, Sarwar M, Cooper JB, Wood SP, Shoolingin-Jordan PM. Structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria. Biochem J. 2009 Apr 28;420(1):17-25. PMID:19207107 doi:10.1042/BJ20082077
2. ↑ Jordan PM, Warren MJ. Evidence for a dipyrromethane cofactor at the catalytic site of E. coli porphobilinogen deaminase. FEBS Lett. 1987 Dec 10;225(1-2):87-92. PMID:3079571