Simvastatin Synthase

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Revision as of 00:17, 13 March 2011 by Eric Ginter (Talk | contribs)
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PDB ID 3hle

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3hle, resolution 2.06Å ()
Ligands: ,
Related: 1hld
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Introduction

Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways ofAspergillus terreus. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin.Image:LovD copy.jpg 

LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Eric Ginter, David Canner, Alexander Berchansky

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