2zb0

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Image:2zb0.png

Template:STRUCTURE 2zb0

Crystal structure of P38 in complex with biphenyl amide inhibitor

Template:ABSTRACT PUBMED 18006306

About this Structure

2ZB0 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL. Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode. Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306 doi:10.1016/j.bmcl.2007.10.076
  • Angell RM, Angell TD, Bamborough P, Brown D, Brown M, Buckton JB, Cockerill SG, Edwards CD, Jones KL, Longstaff T, Smee PA, Smith KJ, Somers DO, Walker AL, Willson M. Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR. Bioorg Med Chem Lett. 2008 Jan 1;18(1):324-8. Epub 2007 Oct 17. PMID:17981461 doi:10.1016/j.bmcl.2007.10.043

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