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2wsa

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Revision as of 22:27, 14 March 2011 by OCA (Talk | contribs)
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Image:2wsa.png

Template:STRUCTURE 2wsa

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND (DDD85646)

Template:ABSTRACT PUBMED 20360736

About this Structure

2wsa is a 1 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA.

Reference

  • Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature. 2010 Apr 1;464(7289):728-32. PMID:20360736 doi:10.1038/nature08893
  • Price HP, Menon MR, Panethymitaki C, Goulding D, McKean PG, Smith DF. Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites. J Biol Chem. 2003 Feb 28;278(9):7206-14. Epub 2002 Dec 17. PMID:12488459 doi:10.1074/jbc.M211391200

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