2gnl

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Image:2gnl.png

Template:STRUCTURE 2gnl

PKA threefold mutant model of Rho-kinase with inhibitor H-1152P

Template:ABSTRACT PUBMED 16699172

About this Structure

2GNL is a 2 chains structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Bonn S, Herrero S, Breitenlechner CB, Erlbruch A, Lehmann W, Engh RA, Gassel M, Bossemeyer D. Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity. J Biol Chem. 2006 Aug 25;281(34):24818-30. Epub 2006 May 12. PMID:16699172 doi:10.1074/jbc.M512374200
  • Breitenlechner C, Gassel M, Hidaka H, Kinzel V, Huber R, Engh RA, Bossemeyer D. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure. 2003 Dec;11(12):1595-607. PMID:14656443

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