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2cbm

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Image:2cbm.png

Template:STRUCTURE 2cbm

CRYSTAL STRUCTURE OF THE APO-FORM OF A NEOCARZINOSTATIN MUTANT EVOLVED TO BIND TESTOSTERONE.

Template:ABSTRACT PUBMED 16529771

About this Structure

2cbm is a 1 chain structure with sequence from Streptomyces carzinostaticus. Full crystallographic information is available from OCA.

Reference

  • Drevelle A, Graille M, Heyd B, Sorel I, Ulryck N, Pecorari F, Desmadril M, van Tilbeurgh H, Minard P. Structures of in vitro evolved binding sites on neocarzinostatin scaffold reveal unanticipated evolutionary pathways. J Mol Biol. 2006 Apr 28;358(2):455-71. Epub 2006 Feb 20. PMID:16529771 doi:10.1016/j.jmb.2006.02.002
  • Heyd B, Pecorari F, Collinet B, Adjadj E, Desmadril M, Minard P. In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein. Biochemistry. 2003 May 20;42(19):5674-83. PMID:12741824 doi:10.1021/bi0273664

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