3acx

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Image:3acx.jpg

Template:STRUCTURE 3acx

Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with BPH-673

About this Structure

3ACX is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

  • Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 7;319(5868):1391-4. Epub 2008 Feb 14. PMID:18276850
  • Song Y, Liu CI, Lin FY, No JH, Hensler M, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AH, Oldfield E. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J Med Chem. 2009 Jul 9;52(13):3869-80. PMID:19456099 doi:10.1021/jm9001764

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