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This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.

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Geneticin

Geneticin, also known as G418, belongs to a group of positively charged sugar derivatives known as aminoglycosides. Aminoglycosides contain three rings that possess hydroxyl, ammonium, and methyl groups.^[1] This groups of proteins bind to different regions of the 30S particle of the ribosome during protein synthesis and interfering with the process. The different regions of the ribosome they bind to depend on their chemical structures. Because geneticin is capable of binding to the 80S ribosome, it is known to be toxic to eukaryotic organisms. However, studies have shown that geneticin can be used in medicine to treat parasites and in the treatment of genetic disorders.

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Contents 1 Geneticin 1.1 Structure 1.2 Function 2 Notes and References 3 Notes and Literature References

Structure

Geneticin contains three rings which are functionalized by hydroxyl, ammonium and methyl groups. When geneticin is bound to the

Function

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Notes and References

1. ↑ 1mwl

Notes and Literature References