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spinqualitylabelsall models PDB ID 2fbv Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2fbv, resolution 2.40Å ()
Ligands:
Gene:	WRN, RECQ3, RECQL2 (Homo sapiens)
Related:	2fbt, 2fbx, 2fby, 2fc0
Structural annotation: Resources: InterPro : Ipr004589, Ipr014021, Ipr014001, Ipr002464, Ipr001650, Ipr002121, Ipr002562, Ipr012337, Ipr011545 Pfam : PF01612 UniProt : Q14191
Functional annotation: Cellular component: nucleus intracellular Biological process: regulation of growth rate aging DNA recombination telomere maintenance Molecular function: 3'-5' exonuclease activity hydrolase activity DNA binding helicase activity nucleotide binding ATP binding DNA helicase activity nucleic acid binding protein binding ATP-dependent helicase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Werner (WRN) protein is one of the five human RecQDNA helicases, which perform DNA replication, recombination, and repair. This enzyme has a helicases function (unwinding the DNA helix) and a nuclease function (degrading), which allows for deletion of mutation and proofreading. The WRN has a functional exonuclease domain located on the N-terminus. WRN protein protects human from cancer; as well as, premature aging.

Contents 1 Function 2 Structure 2.1 Crystallization 2.2 Active Site 2.3 Substrate-Binding Site 3 Clinical significance 4 Reference

Function

Structure

WRN is a enzyme with both magnesium and ATP-dependent DNA-helicase activity with a 3'->5' exonuclease activity towards double-stranded DNA. Magnesium

Crystallization

Active Site

Substrate-Binding Site

Clinical significance

When the gene coding for WRN is mutated a autosomal recessive disorder causing rapid aging(osteoporosis, atherosclerosis and cancer). This is known as Werner syndrome which appears at puberty.

Reference