Inositol Monophosphatase

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Inositol Monophosphatase (1dk4)

This protein structure is derived from the the methanogen Methanococcus jannaschii (MJ0109). Curiously this protein shows both Inositol Monophosphate (IMPase) activity as well as Fructose 1,6 Bisphosphatase acivity (FBPase)[1] 1lbv Template:STRUCTURE 1dk4

Contents

Methanococcus jannaschii

Inisitol Monophatase Structure

Discovery

it is cool[2]

Structures

Ligands

Reaction

References

  1. ↑ Stieglitz KA, Johnson KA, Yang H, Roberts MF, Seaton BA, Head JF, Stec B. Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. J Biol Chem. 2002 Jun 21;277(25):22863-74. Epub 2002 Apr 8. PMID:11940584 doi:http://dx.doi.org/10.1074/jbc.M201042200
  2. ↑ Stec B, Yang H, Johnson KA, Chen L, Roberts MF. MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase. Nat Struct Biol. 2000 Nov;7(11):1046-50. PMID:11062561 doi:10.1038/80968

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Michal Harel, Kadagn Klepsch, OCA, Alexander Berchansky

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