Proliferating Cell Nuclear Antigen
From Proteopedia
Proliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, i.e. the crystal structure of Proliferating Cell Nuclear Antigen from Archaeglobus fulgidus (1rwz).
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3D Structures of Proliferating Cell Nuclear Antigen
Unliganded PCNA
1rwz – AfPCNA - Archaeglobus fulgidus
3lx1 - TkPCNA1 - Thermococcus kodakarensis
3lx2 - TkPCNA2
3lox, 1plq, 1plr – yPCNA - yeast
1vym, 1w60 – hPCNA - human
2io4 – SsPCNA B (mutant) + PCNA C - Sulfolobus solfataricus
2hii, 2hik, 2ixi - SsPCNA A + PCNA B + PCNA C
2nti - SsPCNA A + PCNA B (mutant) + PCNA C
2ijx - SsPCNA A
1iz4, 1iz5 – PfPCNA (mutant) - Pyrococcus furiosus
PCNA + Dpo
2zvk – hPCNA + hDpo ε
2zvl – hPCNA + hDpo κ
2zvm – hPCNA + hDpo τ
3fds – SsPCNA B + PCNA C + SsDpo IV
3a2f - PfPCNA + Dpo
PCNA complexes
1vyj, 1u76, 1u7b – hPCNA + peptide
3p83 - AfPCNA + RNase HII
1rxm – AfPCNA + FEN-1 peptide
1rxz - AfPCNA + Flap structure-specific endonuclease
3l0w, 3l10 - yPCNA + monoubiquinated PCNA
1sxj – yPCNA + replication factor C
2izo - SsPCNA B + PCNA C + Flap structure-specific endonuclease
1isq - PfPCNA (mutant) + replication factor C large subunit
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Lukáš Cakl, Joel L. Sussman
