Colicin S4

From Proteopedia

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spinqualitylabelsall models PDB ID 3few Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
3few, resolution 2.45Å ()
Ligands:
Structural annotation: Resources: InterPro : Ipr000293 Pfam : PF01024
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Colicin S4 is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them by forming a pore in the membrane, leading to depolarisation of the membrane which kills the cell.

Synthesis and release

Colicin S4 is encoded on a plasmid operon, which also encodes its Colicin Immunity Protein, Csi to protect the cell making it from the cytotoxic activity. The colicin is produced in response to stresses such as nutritional deficiency to increase chances of survival when in competition with neighbouring cells. Also encoded in the same operon is the colicin release protein which helps the colicin leave the cell.

Mechanism of uptake

Killing Activities