Cloacin DF13
From Proteopedia
Cloacin DF13 is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them with its 16s rRNase activity; it digests the 16s ribosomal subunit, ultimately leading to the death of the cell. It was initially discovered in Enterobacter cloacae, which gives it its name.
Synthesis and release
The operon encoding Cloacin DF13 is encoded on a plasmid in the producing cell. This operon also includes the Colicin Immunity Protein, and a protein to enable release of the cloacin to the surrounding area. The immunity protein binds to the cytotoxic domain of the cloacin to inhibit its 16s rRNase activity, and protect the producing cell.
