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Contents 1 InhA 1.1 Introduction 1.2 Structure 1.3 Physiological Function 1.4 Role in the Mycolic Acid Pathway 1.5 Protein Superfamilly 1.6 References

InhA

by Kelly Hrywkiw

spinqualitylabelsall models PDB ID 2h9i Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2h9i, resolution 2.20Å ()
Ligands:
Gene:	inhA (Mycobacterium tuberculosis)
Activity:	[acyl-carrier-protein_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number 1.3.1.9
Related:	1zid
Structural annotation: Resources: InterPro : Ipr014358, Ipr002198 UniProt : P0A5Y6
Functional annotation: Biological process: lipid biosynthetic process response to antibiotic fatty acid biosynthetic process metabolic process Molecular function: enoyl-[acyl-carrier-protein reductase (NADH) activity] oxidoreductase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Introduction

InhA is a enoyl-acyl ACP carrier protein that plays a role in the sysnthesis of Mycolic Acid ^[1].

Structure

Physiological Function

Role in the Mycolic Acid Pathway

Protein Superfamilly

References

1. ↑ Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC. Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16. PMID:17227913 doi:10.1084/jem.20062100